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ISU researcher caught faking AIDS research
12-29-2013, 08:08 PM,
ISU researcher caught faking AIDS research
ISU researcher quits amid allegations of AIDS-research fraud involving millions of federal dollars

3:51 PM, Dec 23, 2013 | by Tony Leys |

An Iowa State University professor has resigned after being accused of spiking rabbit blood to make it appear that an AIDS vaccine was working better in the research animals than it really was.

isu-logo1Dr. Dong-Pyou Han was an assistant professor of biomedical sciences. He resigned in October after admitting responsibility, an ISU spokesman said.

The fraudulent results helped an ISU research team gain millions of dollars in federal money, according to Dr. James Bradac, who helps oversee AIDS vaccine grants for the National Institutes of Health.

Bradac said in a phone interview Monday that Han apparently added human blood components to the rabbit blood to skew the results. The human blood came from people whose bodies had produced antibodies to HIV, the virus that causes AIDS, Bradac said. The presence of these antibodies in the rabbits’ blood made it appear that the vaccine was spurring the animals to build defenses against HIV. “This positive result was striking, and it caught everybody’s attention,” Bradac said.

Federal documents released Monday show the results were presented at numerous scientific meetings over several years. But researchers at other institutions became suspicious after they were unsuccessful in duplicating the ISU results.

The ISU team is led by Dr. Michael Cho, a biomedical professor who came to Ames several years ago from Case Western Reserve University in Ohio. Bradac said Cho started receiving federal grants for the research in 2008, when he was at Case Western. Bradac said Han worked for Cho for about 15 years, and transferred to ISU with him. In all, the team was awarded about $19 million in multi-year grants, which also financed related research at several institutions. About $10 million of that money was awarded after Cho’s team reported “exciting results” that now appear to have been fraudulent, Bradac said.

University spokesman John McCarroll said Cho was alerted in January to possible problems with his team’s experiments. “At Iowa State’s request, the research samples in question were examined by researchers at another university; they confirmed samples had been spiked,” McCarroll wrote in an email to the Register.

McCarroll said Han was identified in August as the likely suspect. “He later admitted responsibility and resigned from Iowa State, effective Oct. 4, 2013,” the spokesman said. Cho does not face discipline in the matter, McCarroll said.

Han could not be reached for comment. Cho did not respond immediately to requests for comment.

Bradac, the federal administrator, said Han apparently acted without the knowledge of the rest of his team. “A large amount of what they were focusing on was flushed down because of this one guy,” he said.

The vaccine testing was central to the $19 million in grants, but other activities also were covered by the money, Bradac said. About $4 million has yet to be spent. The federal agency is talking to ISU leaders about whether that money still will be disbursed. Bradac said it’s unusual for a university to have to repay research grant money, though he said he didn’t know if such a refund might be requested in this case.

Bradac said this was the worst case of research misconduct he’d seen in his 24 years at the National Institutes of Health.

Dr. Ivan Oransky, a physician and medical journalist, wrote about the sanctions against Han Monday morning on a blog called “Retraction Watch.” Oransky, who works in New York, said it’s important for researchers to be held accountable for misconduct. This case stands out from most others, he said. “It’s unusual to see someone fake results this brazenly.” Most incidents of misconduct involve someone writing down false data, not altering physical evidence, he said.

The federal documents, which were posted on a government website, say Han agreed to be banned from participating in any federally-financed research for three years. Oransky said that’s an unusually strong penalty.

Oransky said the federal documents suggest ISU officials promptly looked into the suspicions of fraud, and reported their findings. That’s a good sign, he said. Too often, he said, research institutions cover up misconduct or publish opaque accounts that fail to make clear what happened. However, he said, senior faculty should be held accountable in such cases, because they’re supposed to monitor their staff members’ work.

Oransky said he hopes federal prosecutors look into the allegations that millions of taxpayer dollars were awarded based on lies. “This is fraud, and the question is whether it’s a big enough case for the government to go after,” he said. “…I think it’s time for the government to criminally prosecute more of these cases.”
One of the first duties of the physician is to educate the masses not to take medicine...
William Osler
12-30-2013, 02:39 PM,
RE: ISU researcher caught faking AIDS research
Get caught stealing federal grant money.

Get banned from stealing for *three* whole years.

Gotta love government.
12-30-2013, 05:58 PM, (This post was last modified: 12-30-2013, 06:40 PM by Watchdog.)
RE: ISU researcher caught faking AIDS research
Hmmm... What I see from this is a fraud on top of a fraud~!

It has never been proven that AIDS is caused by the so called HIV virus. Many claim it is non-viral. But I'm not going to get into that for now (listen to my podcast if you want more info: Therefore any attempt at making a vaccine is pointless, a fraud on top of a fraud. Having said that you can bet that a vaccine will one day be sold on the market and make BIG PHARMA more money.

As such, this "news story" about a fraud is useful for those that want us to beLIEve the AIDS-HIV hypothesis.

All those that take AIDS drugs are not helping their immune system to recover from whatever killed it in the first place. Please do your own research before taking any anti-viral or vaccines drugs!
Paix, Amour et Lumiere
01-03-2014, 10:19 PM,
RE: ISU researcher caught faking AIDS research
(12-30-2013, 05:58 PM)Watchdog Wrote: Having said that you can bet that a vaccine will one day be sold on the market and make BIG PHARMA more money.

Yea, they're developing a vaccine for obesity, they said it's vaccine related, are you aware of that?!
Obesity Vaccine May Be Ready In Five Years, Researchers Say


"Researchers say" that it already works on mice!

Antiobesity 'Flab-Jab' Vaccine Works in Mice

Ron Zimmerman
September 27, 2012

September 27, 2012 (San Antonio, Texas) — A mouse study presented here this week at Obesity 2012, the annual scientific meeting of the Obesity Society, offers an enticing hint that an obesity vaccine targeting the hormone somatostatin may one day help humans to modulate body weight.

"The original impetus was to look at vaccines against the hormone somatostatin to produce lean meat in pigs and increase milk production in dairy cows," Keith Haffer, PhD, from Braasch Biotech in Garretson, South Dakota, told Medscape Medical News. "Extrapolation showed we could use a similar vaccine mechanism to fight obesity in an obese mouse model."

Researchers gave a vaccine containing purified chimeric somatostatin protein to obese mice on high-fat diets on day 1, followed by a smaller dose on day 22, and compared 6-week outcomes with a control group. "While the control mice continued to gain weight, vaccinated mice lost up to 20% of their body weight within the first week and maintained the weight loss over the 3-week period. We gave them 2 vaccinations, and each vaccination caused weight loss."

According to Dr. Haffer, the vaccine works like any other vaccine in that the body produces immune responses against the antigen contained in the vaccine. What's different, however, is that the new vaccine's effect tapers off rather quickly.

"Every vaccination is considered to be its own vaccine," Dr. Haffer said. "There's no memory response to the somatostatin antigen, which makes it totally unique in vaccines. By the intramuscular route, which is how most vaccinations are given, the maximum response occurred about 2 weeks after vaccination. And it's gone by 4 weeks. So a second dose is administered at that time."

Dr. Haffer says his first study, published online July 9 in the Journal of Animal Science and Biotechnology, prompted worldwide media attention. Some outlets "called it 'the flab jab,' which we think is derogatory, but it certainly gets the point across that there could be a vaccine against obesity."

Dr. Haffer says he thinks human trials could be ready within a year, although he also believes an intermediate animal model will be needed for toxicology studies.

One corollary to the weight loss is that insulin levels are unaffected. "We checked insulin levels, and all the mice insulin levels were the same after vaccinations. That's a very interesting concept."

Commenting on the study, Sabyasachi Sen, MD, PhD, from Baystate Medical Center in Amherst, Massachusetts, cautioned: "One-shot solutions for complex human diseases rarely work. A vaccine may be possible, but diabetes and obesity are multifaceted diseases.... The issue is that this vaccine may not just target one entity, [insulin-like growth factor-1] IGF-1. Somatostatin will affect all the hormones in the body, including the good ones, like normal growth hormone. It's going to reduce tons of other hormones that we need for everyday living. That's the problem: it may not be reducing only one of the peaks of the total iceberg."

But Dr. Erik Hemmingsson, MSc, PhD, from Karolinska Institutet in Stockholm, Sweden, thought that antiobesity vaccines may be exactly what the field needs, calling them a "hot topic."

"We need this kind of outside-the-box thinking. We can't continue these increasing rates of bariatric surgery, which is a measure of our desperation that we don't have better therapies," Dr. Hemmingsson said. "Perhaps this is one more therapy for individualized treatment that might be different for me and for you and for everyone else."

Dr. Haffer is president and chief scientific officer of Braasch Biotech, which manufactures vaccines. Dr. Sen and Dr. Hemmingsson have disclosed no relevant financial relationships.

Obesity 2012. Poster 188-P. Presented September 23, 2012.


No financial relationships!

Not only that but the pioneers at Nabi Pharmaceuticals of Rockville, Md, had developed a anti-smoking vaccine,


it's safe and well tolerated!

But for some foolish reason, the stone-age troglodytes at think that it's insane!

Quote:Will Anyone in Their Right Mind Actually Buy Into These Three New Vaccines?
November 07, 2009
[Image: 11.7vaccine.jpg]

A storm has erupted over the announcement last month that an experimental AIDS vaccine tested in Thailand proved modestly effective. It was billed as a major scientific advance — the long-awaited hard evidence that it is possible to inoculate people against AIDS. But now the trial has been called into question in a way that is overblown and possibly destructive.

But this isn’t the first time the efficacy and safety of a vaccine has been called into question. The government recently announced that $10 million of stimulus money would be used to fund a phase 3 clinical trial of a promising anti-smoking vaccine produced by Nabi Pharmaceuticals of Rockville, Md. However, another company working on a similar vaccine has not been so successful.

Cytos Biotechnology Ltd. said this week that a trial of its nicotine vaccine had failed to reduce smoking behaviors. The study, which is continuing, involved 200 smokers who were motivated to quit. The researchers found that the vaccine, designed to bind nicotine in the blood and prevent it from reaching the brain, was safe and well tolerated. But apparently it did not stimulate high enough levels of antibodies to produce the desired response.

The moment evidence was found that obesity may be linked to a virus, opportunistic drug company researchers dove into developing an “obesity vaccine.” Now researchers say their obesity vaccine could be ready for market in five years. Searching for genetic clues to the obesity epidemic, in the hopes of developing a vaccine against it, is not the answer.

One of the first duties of the physician is to educate the masses not to take medicine...
William Osler

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