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Cure for common cold on cards after medical breakthrough
11-02-2010, 04:35 PM,
Cure for common cold on cards after medical breakthrough
Quote:For the first time, scientists have found that antibodies can operate even after a virus enters healthy cells – rather than just by preventing the virus from invading.

The breakthrough could spawn new generation of antiviral drugs that fight infections by bolstering the body's own defences.

Experts said pills or powders could be on the market within a decade, sparing tens of millions of people from viruses such as the common cold and the winter vomiting virus.

The study, which is reported in the journal Proceedings of the National Academy of Sciences, found that antibodies can enter cells at the same time as the virus invades, triggering of reactions which allows a protein called TRIM21 to eject the bug.

Dr Leo James, the lead author of the study at Cambridge University, said: “Doctors have plenty of antibiotics to fight bacterial infections but few anti-viral drugs.

“Although these are early days, and we don’t yet know whether all viruses are cleared by this mechanism we are excited that our discoveries may open multiple avenues for developing new drugs.”

For those who do not want to wait 10 years for a cure, a separate study in the US found yesterday that taking regular exercise can cut the chance of catching a cold by half and can also reduce the severity of symptoms.

American researchers at Appalachian State University found that bouts of exercise cause a temporary rise in immune system cells circulating around the body.

After studying 1,000 adults aged up to 85, whose respiratory health was tracked for 12 weeks during the autumn and winter of 2008, they concluded that bouts of exercise spark a temporary rise in immune system cells circulating around the body.

While these levels fall back within a few hours, each exercise session "may improve immunosurveillance against pathogens that reduce overall upper respiratory tract infection incidence and symptomatology", they concluded.

The study also backed up previous findings that eating a lot of fruit and not being stressed reduced the frequency of colds.
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11-02-2010, 10:18 PM,
RE: Cure for common cold on cards after medical breakthrough
Is it just me, or does anyone else find this article strange? It seems like such a simple finding, yet it's taken this long for someone to discover it? It really took almost 250 years (since the first recorded cases of vaccination,) to come up with the idea to test the effectiveness of antibodies during or after exposure to a virus? That's really curious to me... I also find it odd that there's absolutely no mention of the flu, only the "winter vomiting virus" and that they're projecting a ten-year time-line on this type of medication's release. That seems like a long time for a "new discovery" that's this promising.
[Image: conspiracy_theory.jpg]
11-04-2010, 10:57 PM, (This post was last modified: 11-04-2010, 11:12 PM by drew hempel.)
RE: Cure for common cold on cards after medical breakthrough
Well hell I'll google the author of the study for you and see what I can find....

Dr Leo James.

"Despite extracellular adaptive and innate immunity, viral and bacterial pathogens are still able to infect cells. Because of this there must be a way to neutralise pathogens once they are inside the cell. Historically, infected cells have been seen as largely helpless and only able to signal for help. However, there is increasing evidence that cells have their own mechanisms for directly restricting pathogen replication. It is this process of intracellular immunity that my lab is interested in."

Previously, it was believed that antibodies could only attack viruses outside cells or by blocking their entry into cells.

Once antibodies enter cells they quickly trigger a response, led by a protein called TRIM21 that pulls the virus into a disposal system used by the cell to get rid of unwanted material. Release of the TRIM21 protein is so quick that the virus is not given a chance to harm the cell.

It was also found that increasing the amount of TRIM21 protein in cells makes this process even more effective, suggesting new ways of making better antiviral drugs.

The research team however, stressed that it would take years of work and testing to find new therapies, and that their discovery would not work on all viruses

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