Thread Rating:
  • 0 Vote(s) - 0 Average
  • 1
  • 2
  • 3
  • 4
  • 5
Scientists discover how to 'switch off' pain of migraines
09-27-2010, 03:32 PM,
Scientists discover how to 'switch off' pain of migraines
Quote:The "once in a generation" finding could allow scientists to create a new generation of drugs that can simply turn down up the theshold at which the body fells pain.

The international study, including scientists at Oxford University, found that a gene called TRESK appears to be fundamental in causing migraines.

It is believed that it controls the sensitivity of pain nerves in the brain and if faulty can bring the threshold so low that just living is painful.

This is why migraine sufferers are so sensitive to light, sounds and even touch.

But the gene is also susceptible to being switched on and off with drugs which means that it could be altered to increase the threshold to such an extent it eliminates the feeling of pain altogether.

"We are really excited about this," said Dr Zameel Cader, a consultant neurologist at the Medical Research Council Functional Genomics Unit at the University of Oxford.

"It is a once in a generation find that could one day lead to treatments that could prevent migraines. Potentially it is even more exciting than that.

"It could potentially lead to a treatment for pain in general. That could impact everybody."

Around 18 per cent of women and eight per cent of men in Britain suffer from migraines which can last up to three days.

There are an estimated 190,000 attacks a day and more than 25 million working days a year are lost through the illness.

A migraine is a severe, long-lasting headache usually felt as a throbbing pain at the front or on one side of the head.

Some people can have a warning visual "sign" before the start of the headache called an aura and many people also have symptoms, such as nausea and sensitivity to light during the headache itself.

Until now, the genes responsible have been unknown. The World Health Organisation (WHO) rates migraine as a leading cause of disability worldwide and it has been estimated to be the most costly neurological disorder in Europe.

Scientists from Canada and Britain looked at the DNA make up of 110 migraine sufferers and their families. They found that a mutation in the TRESK gene appeared to be key cause of the condition – which is also hereditary.

The discovery was exciting because TRESK controls the sensitivity of pain nerves in the trigeminal ganglion, an area at the base of the brain.

The study found that if the gene known as TRESK does not work properly, it can more easily trigger pain centres in the brain and cause a severe headache.

The study is published in Nature Medicine.

The discovery of the gene means that scientists have a whole new pathway to controlling pain.

Whereas painkillers work by numbing pain, this could effectively make the body immune to it.

It was funded by the Medical Research Council, Genome Canada, Genome Quebec, Emerillon Therapeutics, the Wellcome Trust and Pfizer.

“We have now made a major step forward in our understanding of why people suffer with migraine and how in certain cases, your family can literally give you a headache," said Dr Cader.

"Previous studies have identified parts of our DNA that increase the risk in the general population but have not found genes which can be directly responsible for common migraine.

"What we’ve found is that migraines seem to depend on how excitable our nerves are in specific parts of the brain.

"Finding the key player which controls this excitability will give us a real opportunity to find a new way to fight migraines and improve the quality of life for those suffering.”

Lee Tomkin, director of Migraine Action, said: "This is almost a red letter day for migraine sufferers. It is fantastic news and has a lot of implications. This is genuinely a really great step forward."
The revolution is not an apple that falls when it is ripe. You have to make it fall. - Che Guevara

Resistance Films Youtube Channel

TriWooOx Podcast
09-27-2010, 07:20 PM,
RE: Scientists discover how to 'switch off' pain of migraines
I'm guessing this would probably work well for phantom limb pain as well. I wonder how it effects endorphin receptors? That is, if you were to use something like this would you still "feel the burn" during a workout? would junkies have a new treatment for withdrawals? So many prospects, some of them terrifying, some tantalizing.

[Image: conspiracy_theory.jpg]
09-28-2010, 02:27 AM,
RE: Scientists discover how to 'switch off' pain of migraines
What if, just what if a migraine is the bodies way of saying something is wrong. Max Gerson had migraines, remember. My old foster parent gets them REALLY bad if he eats cheese, or before falling to sleep if he's had high amounts of sugar after about 3pm! Strange huh?
"He that saith he abideth in him ought himself also so to walk, even as he walked." -- 1 John 2:6
"Whatever affects one directly, affects all indirectly... This is the interrelated structure of reality." -- Martin Luther King Jr.
"He that answereth a matter before he heareth it, it is folly and shame unto him." -- Proverbs 18:13
"Everyone thinks of changing the world, but no one thinks of changing himself." -- Leo Tolstoy
"To love is to be vulnerable" -- C.S Lewis

The Kingdom of God is within you! -- Luke 17:20-21

Possibly Related Threads...
Thread Author Replies Views Last Post
  Scientists Have Developed a Flu Strain Capable of Evading Your Immune System vagabonder 3 502 07-04-2014, 08:19 AM
Last Post: rockingtheboat
  Chemtrail pilot forgets to switch off aerosols Krise 5 597 05-13-2014, 04:53 PM
Last Post: CharliePrime
  Twenty-year hiatus in rising temperatures has climate scientists puzzled SiLVa 3 944 04-10-2013, 10:24 PM
Last Post: Watchdog
  Watching TV before you go to bed gives you a bad night's sleep and can lead to chronic health problems, scientists h April 1 1,044 01-24-2013, 09:18 PM
Last Post: FastTadpole
  Florida scientists prepare to release genetically modified mosquitoes TriWooOx 2 707 12-08-2012, 12:53 PM
Last Post: psilocybin
  Bill Gates backs climate scientists lobbying for large-scale geoengineering TriWooOx 1 726 08-05-2012, 12:11 AM
Last Post: yeti
  New flu virus found in seals concerns scientists TriWooOx 1 622 07-31-2012, 06:57 PM
Last Post: yeti
  British GM crop scientists win $10m grant from Gates TriWooOx 0 463 07-15-2012, 01:39 PM
Last Post: TriWooOx
  Scientists: Far more cesium released than previously believed yeti 4 947 03-07-2012, 09:58 PM
Last Post: FastTadpole
  Scientists Say Delay Breastfeeding to ‘Improve’ Vaccine Potency yeti 1 769 01-23-2012, 11:23 AM
Last Post: nwo2012

Forum Jump:

Users browsing this thread: 1 Guest(s)