Thread Rating:
  • 0 Vote(s) - 0 Average
  • 1
  • 2
  • 3
  • 4
  • 5
Simple cure for Bisphenol A: HEADACHE TABLETS!
07-11-2010, 09:38 PM,
#1
Exclamation  Simple cure for Bisphenol A: HEADACHE TABLETS!
A 2009 research has found that some drugs, like naproxen, salicylic acid, carbamazepine and mefenamic acid can, in vitro, significantly inhibit BPA glucuronidation.

Naproxen and naproxen sodium are marketed under various trade names including: Aleve, Anaprox, Antalgin, Feminax Ultra, Flanax, Inza, Midol Extended Relief, Miranax, Naposin, Naprelan, Naprogesic, Naprosyn, Narocin, Proxen, Synflex, Xenobid.

Salicylic acid (from Latin salix, willow tree, from the bark of which the substance is obtained) is a compound that is chemically similar to but not identical to the active component of aspirin (acetylsalicylic acid), it is probably best known for its use in anti-acne treatments.

Carbamazepine has been sold under the names Tegretol, Biston, Calepsin, Carbatrol, Epitol, Equetro, Finlepsin, Sirtal, Stazepine, Telesmin, Teril, Timonil, Trimonil, Epimaz, Carbama/Carbamaze (New Zealand), Amizepin (Poland), Hermolepsin (Sweden), and Degranol (South Africa).

Mefenamic acid is marketed in the USA as Ponstel.

http://informahealthcare.com/doi/abs/10.3109/00498250903383334

Quote:High concentrations of commonly used drugs can inhibit the in vitro glucuronidation of bisphenol A and nonylphenol in rats

February 2010, Vol. 40, No. 2 , Pages 83-92 (doi:10.3109/00498250903383334)

M.-A. Verner, T. Magher, S. Haddad

Département des sciences biologiques, Université du Québec à Montréal, Montréal, Quebec, Canada
Address for Correspondence:Sami Haddad, Université du Québec à Montréal, C.P. 8888 Succ. Centre-Ville, Montréal (Québec), Canada H3C 3P8. Tel: 514-987-3000 ext. 2451. Fax: 514-987-4647. Email: haddad.sami@uqam.ca


1.

4-n-Nonylphenol and bisphenol A are endocrine disrupting chemicals that are mainly detoxified through glucuronidation. A factor that may modulate their glucuronidation rates is co-exposure to pharmaceuticals.
2.

This study aimed to identify and characterize the potential metabolic interactions between 14 drugs and these two endocrine disruptors.
3.

Nonylphenol and bisphenol A were co-incubated in freshly isolated rat hepatocytes with, drugs at a high concentration. Statistically significant metabolic inhibition of bisphenol A and nonylphenol biotransformation was observed with nine drugs (>50% inhibition by naproxen, salicylic acid, carbamazepine and mefenamic acid). Inhibition assays of UGT activity in rat liver microsomes revealed: 1) competitive inhibition by naproxen (Kiapp = 848.3 μM) and carbamazepine (Kiapp = 1023.1 μM), 2) no inhibition by salicylic acid suggesting another mechanism of inhibition.
4.

Detoxification of nonylphenol and bisphenol A was shown to be impaired by excessive concentrations of many drugs and health risk assessment should therefore address this issue.
Reply
07-12-2010, 12:35 AM,
#2
RE: Simple cure for Bisphenol A: HEADACHE TABLETS!
thanks for the heads up
Reply
07-12-2010, 01:01 AM,
#3
RE: Simple cure for Bisphenol A: HEADACHE TABLETS!
great info, thanx... I wonder if that's mitigated by storing those substances in plastics containing BPA?
[Image: conspiracy_theory.jpg]
Reply


Possibly Related Threads...
Thread Author Replies Views Last Post
  How to cure/reverse brain damage? ormagus 42 32,112 01-25-2014, 03:44 PM
Last Post: Krise
Information Researchers Describe First 'Functional HIV Cure' in an Infant Frank2 3 595 03-07-2013, 06:23 PM
Last Post: CharliePrime
Question Cure for psoriasis? Nosmokee 5 1,277 09-16-2012, 08:13 PM
Last Post: RaFTertheONE
  Ibogaine -- The Magic Plant That Could Cure Addiction, Still Banned in the U.S. mastermg 7 1,974 08-14-2012, 06:41 AM
Last Post: Harrytyler
  The Cure For Depression!? zoverload 3 788 02-21-2012, 10:44 AM
Last Post: rsol
  Petroleum - the cure Solve et Coagula 7 4,924 09-10-2011, 08:11 AM
Last Post: nwo2012
  Five-step diabetes cure, and why one-third of U.S. adults will have diabetes by 2050 dicktater 3 1,604 08-05-2011, 03:00 AM
Last Post: psilocybin
  Examining The Cancer explosion and the man who claims to have found a cure. Defendfreedom 0 658 06-22-2011, 08:25 PM
Last Post: Defendfreedom
  Couple Pleads For Safe Return Of Laptop Containing Cancer Cure Research drummer 2 709 01-16-2011, 05:57 AM
Last Post: Dunamis
  Cure for common cold on cards after medical breakthrough TriWooOx 2 837 11-04-2010, 10:57 PM
Last Post: drew hempel

Forum Jump:


Users browsing this thread: 1 Guest(s)