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Simple cure for Bisphenol A: HEADACHE TABLETS!
07-11-2010, 09:38 PM,
Exclamation  Simple cure for Bisphenol A: HEADACHE TABLETS!
A 2009 research has found that some drugs, like naproxen, salicylic acid, carbamazepine and mefenamic acid can, in vitro, significantly inhibit BPA glucuronidation.

Naproxen and naproxen sodium are marketed under various trade names including: Aleve, Anaprox, Antalgin, Feminax Ultra, Flanax, Inza, Midol Extended Relief, Miranax, Naposin, Naprelan, Naprogesic, Naprosyn, Narocin, Proxen, Synflex, Xenobid.

Salicylic acid (from Latin salix, willow tree, from the bark of which the substance is obtained) is a compound that is chemically similar to but not identical to the active component of aspirin (acetylsalicylic acid), it is probably best known for its use in anti-acne treatments.

Carbamazepine has been sold under the names Tegretol, Biston, Calepsin, Carbatrol, Epitol, Equetro, Finlepsin, Sirtal, Stazepine, Telesmin, Teril, Timonil, Trimonil, Epimaz, Carbama/Carbamaze (New Zealand), Amizepin (Poland), Hermolepsin (Sweden), and Degranol (South Africa).

Mefenamic acid is marketed in the USA as Ponstel.

Quote:High concentrations of commonly used drugs can inhibit the in vitro glucuronidation of bisphenol A and nonylphenol in rats

February 2010, Vol. 40, No. 2 , Pages 83-92 (doi:10.3109/00498250903383334)

M.-A. Verner, T. Magher, S. Haddad

Département des sciences biologiques, Université du Québec à Montréal, Montréal, Quebec, Canada
Address for Correspondence:Sami Haddad, Université du Québec à Montréal, C.P. 8888 Succ. Centre-Ville, Montréal (Québec), Canada H3C 3P8. Tel: 514-987-3000 ext. 2451. Fax: 514-987-4647. Email:


4-n-Nonylphenol and bisphenol A are endocrine disrupting chemicals that are mainly detoxified through glucuronidation. A factor that may modulate their glucuronidation rates is co-exposure to pharmaceuticals.

This study aimed to identify and characterize the potential metabolic interactions between 14 drugs and these two endocrine disruptors.

Nonylphenol and bisphenol A were co-incubated in freshly isolated rat hepatocytes with, drugs at a high concentration. Statistically significant metabolic inhibition of bisphenol A and nonylphenol biotransformation was observed with nine drugs (>50% inhibition by naproxen, salicylic acid, carbamazepine and mefenamic acid). Inhibition assays of UGT activity in rat liver microsomes revealed: 1) competitive inhibition by naproxen (Kiapp = 848.3 μM) and carbamazepine (Kiapp = 1023.1 μM), 2) no inhibition by salicylic acid suggesting another mechanism of inhibition.

Detoxification of nonylphenol and bisphenol A was shown to be impaired by excessive concentrations of many drugs and health risk assessment should therefore address this issue.
07-12-2010, 12:35 AM,
RE: Simple cure for Bisphenol A: HEADACHE TABLETS!
thanks for the heads up
07-12-2010, 01:01 AM,
RE: Simple cure for Bisphenol A: HEADACHE TABLETS!
great info, thanx... I wonder if that's mitigated by storing those substances in plastics containing BPA?
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