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Researchers Breed Permanently “happy” Mice
09-07-2006, 03:55 PM,
#1
Researchers Breed Permanently “happy” Mice
Aug. 24, 2006
Courtesy McGill University
and World Science staff

A new breed of permanently “cheerful” mouse is providing new hope for treatment of clinical depression, researchers say. [Image: 2mice.jpg] The sci­en­tists stud­ied a gene called TREK-1, which can af­fect the flow of a brain chem­i­cal called ser­o­to­nin. This in turn in­flu­ences mood, sleep and sex­u­al­i­ty.

By breed­ing mice with­out TREK-1, the re­searchers sa­id they cre­at­ed a de­pres­sion-resistant strain.

The find­ings ap­pear in the re­search jour­nal Na­ture Neu­ro­science this week.

“De­pres­sion is a dev­as­tat­ing ill­ness, which af­fects a­round 10 per­cent of peo­ple at some point in their life,” sa­id Guy Debon­nel of McGill U­ni­ver­si­ty in Mont­re­al, Can­a­da, prin­ci­pal au­thor of the pa­per. Cur­rent treat­ments fail for a third of pa­tients, he added.

Sci­en­tists al­so be­lieve mice can suf­fer moods a­kin to hu­man de­pres­sion, ev­i­denced by with­drawn and pas­sive be­hav­ior in the ro­dents. Some of the same brain chem­i­cals have been linked to both hu­man and ro­dent “de­pres­sion.”

Debon­nel’s team tested the new­ly bred mice us­ing “be­hav­ioral, e­lec­tro­phys&shyio­log­i­cal and bio­chem­i­cal meas­ures known to gauge ‘de­pres­sion’ in an­i­mal­s,” he sa­id. “The re­sults re­al­ly sur­prised us. [They] acted as if they had been treated with an­tide­pres­sants for at least three week­s.”

The re­search rep­re­sents the first time de­pres­sion has been e­lim­i­nat­ed by ge­net­i­cal­ly mod­i­fy­ing an or­gan­ism, he added. “The dis­cov­er­y of a link be­tween TREK-1 and de­pres­sion could ul­ti­mate­ly lead to the de­vel­op­ment of a new gen­er­a­tion of an­ti­de­pres­sant drugs.”

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09-08-2006, 03:29 AM,
#2
Researchers Breed Permanently “happy” Mice
Doesn't really need to be said, but: Happy little slaves are next.

Yes Sire, I'd love to work in your polluted factory that will kill me at about age 30.
The belief in 'coincidence' is the prevalent superstition of the Age of Science.

&I don't understand why you're taking such a belligerant tone when you're obviously the ignorant one here. &
-triplesix
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09-08-2006, 06:24 PM,
#3
Researchers Breed Permanently “happy” Mice
lol^^ well said.
[Image: intellektssig.png]

&A stupid man's report of what a clever man says is never accurate because he unconsciously translates what he hears into something he can understand.& -- Bertrand Russell
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