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Mature Human Embryos Created From Adult Skin Cells
01-21-2008, 04:35 PM,
Mature Human Embryos Created From Adult Skin Cells

Quote:[size="2"] Washington Post Staff Writer
Friday, January 18, 2008; Page A01 [/size]

Scientists at a California company reported yesterday that they had created the first mature cloned human embryos from single skin cells taken from adults, a significant advance toward the goal of growing personalized stem cells for patients suffering from various diseases.

This Story
  • European Ethics Group Opposes Food From Cloned Animals<>
  • Mature Human Embryos Created From Adult Skin Cells<>
    [st] Creation of the embryos -- grown from cells taken from the company's chief executive and one of its investors -- also offered sobering evidence that few, if any, technical barriers may remain to the creation of cloned babies. That reality could prompt renewed controversy on Capitol Hill, where the debate over human cloning has died down of late.

    Five of the new embryos grew in laboratory dishes to the stage that fertility doctors consider ready for transfer to a woman's womb: a degree of development that clones of adult humans have never achieved before.

    No one knows whether those embryos were healthy enough to grow into babies. But the study leader, who is also the medical director of a fertility clinic, said they looked robust, even as he emphasized that he has no interest in cloning people.

    "It's unethical and it's illegal, and we hope no one else does it either," said Samuel H. Wood, chief executive of Stemagen in La Jolla, whose skin cells were cloned and who led the study with Andrew J. French, the firm's chief scientific officer.

    The closely held company hopes to make embryos that are clones, or genetic twins, of patients, then harvest stem cells from those embryos and grow them into replacement tissues. When transplanted into patients, the tissues would not be rejected because the immune system would see them as "self."

    "All our efforts are being directed toward personalized medicine and diseases," said Wood, adding that the scientists did not try to extract stem cells from the first embryos they made because they were focused on proving they could make the clones.

    Other stem cell scientists expressed optimism but said they want to see the work repeated and more details presented.

    "I'd really like to believe it, but I'm not sold yet," said Robert Lanza of Advanced Cell Technology (ACT) in Worcester, Mass. He said the report did not show the results of molecular tests that scientists typically do to prove that the cloning process was complete. He and George Daley, a stem cell scientist at Children's Hospital Boston, said the embryos look only marginally healthy in photos.

    The work is the latest evidence, however, that the field is recovering from the scientific and public relations debacle of 2005, when similar claims by South Korean scientists proved to have been fabricated.

    Nevertheless, opponents of research on human embryos lashed out at the approach.

    "This study seems to confirm that human cloning . . . is technically possible," said Richard Doerflinger of the U.S. Conference of Catholic Bishops. "It does not show that a viable or normal embryonic stem cell line can be derived this way, or that any such cell has 'therapeutic' value. It does not answer the ethical or social questions about the mass-production of developing human lives in order to destroy them. . . . It only tells us that these questions are more urgent than ever."

articles continues...
05-16-2013, 05:24 PM,
RE: Mature Human Embryos Created From Adult Skin Cells
Uhm another first. It's official (again) now, not that this type of thing wasn't being done underground for awhile - maybe decades - now. It does use a different process than the article above employed.

Quote:Scientists Create First Cloned Human Embryo
The process that created Dolly the sheep in 1996 has now been proven successful in humans.

Scientists have made an embryonic clone of a person, using DNA from that person's skin cells. In the future, such a clone could be a source of stem cells, for super-personalized therapies made from people's own DNA.


It's unlikely that this clone could develop into a human, say the scientists, a team of biologists from the U.S. and Thailand. The team plans to publish a paper in the future detailing why not, Nature reported. Previously, the team conducted this entire process, including a technique called somatic cell nuclear transfer, in monkeys. Those monkey embryo clones always died before they could grow into adult monkeys.

"While nuclear transfer breakthroughs often lead to a public discussion about the ethics of human cloning, this is not our focus, nor do we believe our findings might be used by others to advance the possibility of human reproductive cloning," Shoukhrat Mitalipov, the clone research's lead scientist, said in a statement. Mitalipov is a biologist who studies cells and development at the Oregon Health and Science University.

This is a feat that's been a long time coming. The world even got a bit of a tease of it nearly a decade ago, in 2004 and 2005, when Woo Suk Hwang of Seoul National University said he'd made human clones. It turned out Hwang was lying.

Now, Mitalipov and his team have made clones using the same basic technique that created Dolly the cloned sheep in 1996. The scientists took skin cells' nuclei—the centers of the cells, where the cells keep their DNA—and transplanted them into eggs that had their own genetic material removed. They then grew the eggs for a few days, harvested the daughter cells that appeared, and created a cell line, or a colony of cells that reproduces stably. The stem cells in the cell line could become several different types of adult cells, just like natural stem cells.

In the future, stem cells made in this way will compete with another method of creating personalized stem cells. Researchers previously showed they are able to transform adult skin cells directly into stem cells, with no stop for a transfer into an egg along the way. Such cells are called induced pluripotent stem cells, or iPSCs, and they don't require the creation of embryos.

Want to learn more? Mitalipov and his colleagues published a paper about their work today in the journal Cell. Nature has great reporting on the breakthrough, with a little more scientific nitty-gritty.

More Links FTA:

Human stem cells created by cloning, Breakthrough sets up showdown with induced adult lines.

Human Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer

OHSU research team successfully converts human skin cells into embryonic stem cells. The breakthrough marks the first time human stem cells have been produced via nuclear transfer and follows several unsuccessful attempts by research groups worldwide
There are no others, there is only us.
05-16-2013, 05:55 PM,
RE: Mature Human Embryos Created From Adult Skin Cells
I bought this album in 1980. As a metal head, I felt ripped-off and swore I would never buy another Alice Cooper album. I didn't.


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